{"id":33841,"date":"2021-06-17T22:19:21","date_gmt":"2021-06-17T20:19:21","guid":{"rendered":"https:\/\/genomtec.com\/?page_id=33841"},"modified":"2026-10-20T14:24:05","modified_gmt":"2026-10-20T12:24:05","slug":"technology","status":"publish","type":"page","link":"https:\/\/testy.genomtec.com\/en\/technology\/","title":{"rendered":"Technology"},"content":{"rendered":"
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Page introduction<\/strong><\/h3>\n

Genomtec develops integrated molecular-diagnostics technologies intended to simplify and accelerate nucleic-acid testing in professional point-of-care and near-patient settings. The technology portfolio combines nucleic acid amplification chemistry, microfluidic reaction cards, optical heating and fluorescence detection, analyser hardware, software and AI-enabled assay-development workflows.<\/strong><\/p>\n

Molecular diagnostics<\/strong><\/h3>\n

Molecular diagnostics identifies defined DNA or RNA sequences associated with pathogens, inherited variants or other clinically relevant biological targets. Real-time PCR remains a widely used amplification method and relies on repeated heating and cooling cycles. Isothermal amplification operates at an approximately constant reaction temperature, enabling a simpler thermal architecture and supporting the development of compact analytical systems.<\/strong><\/p>\n

Development approach<\/strong><\/h3>\n

Genomtec integrates assay development with instrument and reaction-card engineering. This system-level approach is intended to support automated workflows, controlled reaction conditions, real-time signal monitoring and multiplex testing within application-specific product configurations.<\/strong><\/p>\n<\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/section>\n\n

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LAMP<\/h2> <\/div>\n<\/section>\n\n
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Isothermal amplification for rapid molecular testing<\/strong><\/h3>\n

Loop-mediated isothermal amplification, or LAMP, amplifies target nucleic acids at an approximately constant temperature using a strand-displacing polymerase and multiple target-specific primer regions. Reverse-transcription LAMP, or RT-LAMP, adds a reverse-transcription step for RNA targets. Because thermal cycling is not required, LAMP can support compact, energy-efficient analyser designs for decentralised molecular testing<\/p>\n<\/div>\n

Primer architecture and reaction behaviour<\/strong><\/h3>\n

A conventional LAMP assay uses inner and outer primers, with optional loop primers to accelerate amplification. Multiple recognition regions provide strong analytical specificity.<\/p>\n<\/div>\n

Point-of-care relevance<\/strong><\/h3>\n

The constant-temperature reaction format can reduce thermal-system complexity compared with PCR. When combined with suitable sample preparation, closed consumables, optical detection, software controls and quality-control procedures, LAMP can form the basis of automated professional point-of-care workflows.<\/p>\n<\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/section>\n\n

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AI-enabled assay development<\/h2> <\/div>\n<\/section>\n\n
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Genomtec\u2019s AI pipeline transforms primer design for (RT\u2011)LAMP from a manual, heuristic exercise into a data\u2011driven, reproducible process that systematically explores sequence space, balances thermodynamics and kinetics, and anticipates off\u2011target risks before a single tube is run. By coupling reverse\u2011complement\u2011aware sequence models with reinforcement\u2011style search, the system proposes primer sets that are more likely to succeed in-vitro<\/em> and remain stable across genotypes, matrices and use\u2011case conditions. The result is a tangible, end\u2011to\u2011end benefit profile that touches strategy, operations and clinical practice.<\/p>\n<\/div>\n

This pipeline shortens assay development cycles and materially improves the \u201chit rate\u201d of candidate primer sets, which directly reduces wet\u2011lab iteration, reagent consumption and hands\u2011on time. Faster convergence to validated designs accelerates portfolio expansion \u2013 new panels and menu updates move from concept to verification sooner, while preserving analytical rigor.<\/strong><\/p>\n<\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/section>\n\n

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From in-silico design to wet-lab verification<\/strong><\/h2>\n

Genomtec is developing digital and AI-assisted workflows to support target selection, primer generation, sequence screening and candidate ranking for LAMP and RT-LAMP assays. The workflow is designed to process genomic data, evaluate candidate sequences and prioritise primer sets before laboratory testing. This approach particularly important during assay development for emerging pathogens where time is critical to support early responders and control outbreak.<\/p>\n<\/div>\n

A decision-support workflow<\/strong><\/h2>\n

Candidate primer sets are progressed through wet-lab screening, optimisation and verification against defined acceptance criteria. The objective is to reduce unproductive design iterations, improve reproducibility.<\/p>\n<\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/section>\n\n

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Potential partner value<\/strong><\/h2>\n

For diagnostic and life-science partners, the workflow may support faster feasibility assessment, systematic comparison of primer candidates and more structured transfer from in-silico analysis to laboratory verification. Project scope, deliverables and performance criteria should be defined for each collaboration.<\/p>\n<\/div>\n

Variant-aware design<\/strong><\/h2>\n

sequences. This supports early assessment of inclusivity and cross-reactivity risks. Final assay performance, including the effect of variants and sample matrices, must be confirmed experimentally.<\/p>\n<\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/section>\n\n

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SNAAT\u00ae Genomtec<\/h2>

Integrated isothermal-diagnostics architecture<\/h3><\/div>\n<\/section>\n\n
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SNAAT\u00ae is Genomtec\u2019s proprietary approach to integrating isothermal nucleic-acid amplification with microfluidic reaction cards, optical heating and contactless temperature measurement, fluorescence detection and automated system control. The architecture is being developed to support compact molecular-diagnostics workflows.<\/p>\n<\/div>\n

System components
\n<\/strong>Depending on the application and product configuration, a SNAAT\u00ae-based workflow may combine sample handling, nucleic-acid processing, amplification and optical detection. The microfluidic consumable and analyser are developed as an integrated system, allowing fluidic, thermal, optical and software parameters to be controlled together.<\/p>\n<\/div>\n

Multiplexing
\n<\/strong>The reaction-card format is designed to support multiple reaction chambers and parallel detection of defined molecular targets. The number of targets, analytical performance and sample-to-result workflow depend on the specific assay panel and system configuration. Special multiplexing capabilities together with precise heating system allow for uncompromised assay design delivering best testing accuracy.<\/p>\n<\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/section>\n\n

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SNAAT\u00ae vs PCR<\/h2>

Comparison of SNAAT\/LAMP and PCR<\/h3><\/div>\n<\/section>\n\n
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<\/th>LOD & time<\/th>Energy and time
\r\nconsumption<\/th>		Size<\/th><\/tr><\/thead>
SNAAT\/LAMP<\/td>
\"\"<\/figure>Femtogramy
\r\n10-15<\/sup>g<\/td>
\"\"<\/figure>Energy-efficient
\r\nand fast
\r\n<\/td>
\"\"<\/figure>Mobile\t<\/td><\/tr>
PCR<\/td>
\"\"<\/figure>Nanograms
\r\n10-9<\/sup>g<\/td>
\"\"<\/figure>Energy- and
\r\ntime-consuming<\/td>
\"\"<\/figure>Stationary<\/td><\/tr><\/tbody> <\/table>\n <\/div>\n<\/div>\n<\/section>\n\n
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PCR (Polymerase Chain Reaction) is the most often used method in genetic diagnostics. It is one of the genetic amplification (multiplication) methods using the enzymatic process in various temperature ranges. The reaction is initiated by a pair of short nucleotides complementary to DNA strand, so-called primers that guide the enzyme to a suitable amplification initiation site. This method makes it possible to analyze genetic material of low initial concentration. One of the PCR variants is the real-time PCR, where dyes or probes (fluorescently labelled nucleotides) are introduced to the reaction environment and then bind to the target nucleic acid fragment during the analysis.<\/p>\n<\/div>\n

The SNAAT\u00ae method is groundbreaking, as it allows integration of the complete diagnostic process into one platform, thus automating the expensive and time-consuming analytic step of the process that occurs in the diagnostic laboratory by using contactless photonic heating and microfluidics.<\/strong><\/p>\n

The proprietary SNAAT\u00ae method allows:<\/strong><\/p>\n

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  • ensuring the optimum reaction temperature,<\/strong><\/li>\n
  • stabilizing the temperature output and controling fluid flow in the microfluidic system, and<\/strong><\/li>\n
  • analyzing the amplification results (fluoroscence measurement).<\/strong><\/li>\n<\/ul>\n<\/div>\n

    These processes are contactless, using photonic energy, thus revolutionizing the current standard for heating and cooling of the reaction mixture in the PCR test tube, i.e. by placing it in a thermally conductive element, so called thermoblock.<\/p>\n

    Combining contactless heating that utilizes photon energy with microfluidics makes it possible to miniaturize the system and eliminate the energy-consuming heating system based on a physical energy conduction via thermoblock. As a result we gain a mobile and automated diagnostic process.<\/p>\n<\/div>\n <\/div>\n <\/div>\n <\/div>\n<\/section>\n\n

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    Advantages of SNAAT\u00ae over PCR<\/h3><\/div>\n<\/section>\n\n
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    Property<\/th>Current standard<\/th>GENOMTEC solution<\/th>Reason<\/th><\/tr>
    <\/th>PCR<\/th>LAMP\/SNAAT\u00ae<\/th>Consequence of the SNAAT\u00ae innovation<\/th><\/tr><\/thead>
    Reaction temperature<\/td>Variable (three ranges)<\/td>Constant (one range)<\/td>High primer and enzyme efficiency at a reduced temperature<\/td><\/tr>
    Specificity\t<\/td>High\t<\/td>Very high\t<\/td>Higher number of reaction initiating primers<\/td><\/tr>
    Sensitivity\t<\/td>High\t<\/td>Very high\t<\/td>10-100-fold greater reaction efficiency in comparison to the PCR method<\/td><\/tr>
    Repeatability\t<\/td>High\t<\/td>Very high\t<\/td>Automation of analytical process and reaction resistant to inhibitors<\/td><\/tr>
    Analyzer design \t<\/td>Complex optical and heating\/cooling systems\t<\/td>Streamlined optical system, no cooling system\t<\/td>High intensity of fluorescence signal, constant reaction temperature<\/td><\/tr><\/tbody> <\/table>\n <\/div>\n<\/div>\n<\/section>","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":31557,"parent":0,"menu_order":48,"comment_status":"closed","ping_status":"closed","template":"","meta":{"inline_featured_image":false,"footnotes":""},"class_list":["post-33841","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nTechnology - Genomtec TEST<\/title>\n<meta name=\"robots\" content=\"noindex, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Technology - Genomtec TEST\" \/>\n<meta property=\"og:url\" content=\"https:\/\/testy.genomtec.com\/en\/technology\/\" \/>\n<meta property=\"og:site_name\" content=\"Genomtec TEST\" \/>\n<meta property=\"article:modified_time\" content=\"2026-10-20T12:24:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/testy.genomtec.com\/wp-content\/uploads\/2020\/11\/tech_top.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1900\" \/>\n\t<meta property=\"og:image:height\" content=\"250\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebSite\",\"@id\":\"https:\/\/testy.genomtec.com\/#website\",\"url\":\"https:\/\/testy.genomtec.com\/\",\"name\":\"Genomtec TEST\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/testy.genomtec.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-US\"},{\"@type\":\"ImageObject\",\"@id\":\"https:\/\/testy.genomtec.com\/en\/technology\/#primaryimage\",\"inLanguage\":\"en-US\",\"url\":\"https:\/\/testy.genomtec.com\/wp-content\/uploads\/2020\/11\/tech_top.jpg\",\"contentUrl\":\"https:\/\/testy.genomtec.com\/wp-content\/uploads\/2020\/11\/tech_top.jpg\",\"width\":1900,\"height\":250},{\"@type\":\"WebPage\",\"@id\":\"https:\/\/testy.genomtec.com\/en\/technology\/#webpage\",\"url\":\"https:\/\/testy.genomtec.com\/en\/technology\/\",\"name\":\"Technology - 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